Effects of Cortisol and Adrenalectomy on Induction of Interferon by Endotoxin.
- 1 May 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 125 (1), 89-92
- https://doi.org/10.3181/00379727-125-32021
Abstract
Summary The administration of 1 to 5 mg of cortisol to 1 kg rabbits markedly suppressed interferon production by E. coli endo-toxin. Single doses of cortisol, up to 25 mg, did not decrease circulating interferon levels following inoculations with Newcastle disease virus. This type of interferon was only partially suppressed with multiple injections of 250 mg. Thus, administered cortisol inhibited more readily the production of endotoxin-in-duced interferon than the virus-induced counterpart. Adrenalectomy markedly potentiated the production of interferon by endotoxin. Adrenalectomized rabbits inoculated with endotoxin produced serum interferon to a mean titer of 1:388, while the mean titer in control animals was 1:28, suggesting that endogenous steroids suppress the interferon esponse to endotoxin. Mrs. Linda Carcione offered excellent technical assistance. One of us (Miss Catherine DeAngelis) was a recipient of a summer research fellowship under NIH grant 5416-05.This publication has 10 references indexed in Scilit:
- Effects of Cortisol on Interferon Production by Mouse Peritoneal Leukocytes and Spleen in vitro and in vivoExperimental Biology and Medicine, 1966
- Effect of Concomitant Treatment by Cortisone and N-Ethylisatin -Thiosemicarbazone on Neurovaccinia Virus Infected MiceExperimental Biology and Medicine, 1966
- THE INFLUENCE OF CORTISONE ON EXPERIMENTAL VIRAL INFECTIONThe Journal of Experimental Medicine, 1966
- Effect of Temperature on the Induction of Interferons by Endotoxin and VirusJournal of Bacteriology, 1966
- The in Vitro and in Vivo Effects of Cortisol on Interferon Production and ActionThe Journal of Immunology, 1966
- Influence of inhibitors of protein synthesis on interferon formation in miceVirology, 1965
- Interferon Appearance Stimulated by Endotoxin, Bacteria, or Viruses in Mice Pre-Treated with Escherichia coli Endotoxin or Infected with Mycobacterium tuberculosisNature, 1965
- Tolerance to the Induction of Interferons by Endotoxin and Virus: Role of a Humoral Factor.Experimental Biology and Medicine, 1965
- EFFECT OF ACTINOMYCIN D ON VIRUS AND ENDOTOXIN-INDUCED INTERFERONLIKE INHIBITORS IN RABBITSProceedings of the National Academy of Sciences, 1965
- Interferon-Like Viral Inhibitor in Rabbits after Intravenous Administration of EndotoxinScience, 1964