Resorption of bone by mouse peritoneal macrophages

Abstract

An experimental system is described in which mononuclear phagocytes are shown to cause contact‐dependent resorption of bone powder in vitro. Endotoxin, which is known to stimulate macrophage functions, and which has also been shown to increase bone resorption in organ culture, increased bone dissolution by mononuclear phagocytes. On the other hand, parathyroid hormone and prostaglandin E₂, hormones which increase the number and activity of osteoclasts, had no effect on resorption of bone powder by monnuclear phagocytes. This suggests that the osteoclast, which is probably derived from mononuclear phagocytes, is induced to respond to these hormones indirectly, following a primary hormonal effect on osteoblasts.