Mechanism of estrogenic action in acromegaly
Open Access
- 1 February 1969
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 48 (2), 260-270
- https://doi.org/10.1172/jci105982
Abstract
In four acromegalic patients, estrogen therapy did not significantly alter the mean values of basal radioimmunoassayable plasma growth hormone. In two patients, estrogen therapy did not qualitatively alter the lack of reduction of plasma growth hormone levels after oral administration of glucose, nor did it reduce in these patients the response of plasma growth hormone to insulin-induced hypoglycemia. In one of the patients, insulin sensitivity with respect to glucose and the hypoglycemia-induced growth hormone rise seemed greater during estrogen therapy. Despite the absence of demonstrable reductions inplasma growth hormone level under varying experimental circumstances, the administration of estrogen resulted in reduction of urinary calcium and hydroxyproline excretion, in reduction of radiocalcium bone accretion rates and exchangeable pools, in reduction of serum phosphorus, and in more negative nitrogen balances. The experimental data therefore suggest that estrogen may be a peripheral antagonist of the effects of excessive growth hormone secretion in acromegaly.Keywords
This publication has 17 references indexed in Scilit:
- Ability of 47Ca kinetic analysis to discriminate metabolic states affecting bone formation in dogsMetabolism, 1967
- Effect of Estrogen Therapy on Carbohydrate Metabolism in AcromegalyJournal of Clinical Endocrinology & Metabolism, 1967
- Radioactive Calcium Kinetics during High Calcium Intake in Osteoporosis*JCI Insight, 1965
- CRITICAL FACTORS IN EXCESSIVE SERUM-INSULIN RESPONSE TO GLUCOSE OBESITY IN MATURITY-ONSET DIABETES AND GROWTH HORMONE IN ACROMEGALYThe Lancet, 1965
- Metabolic balance studies of high calcium intake in osteoporosisAmerican Journal Of Medicine, 1964
- Immunoassay of Human Growth Hormone in PlasmaNature, 1963
- RELATIONSHIP BETWEEN URINARY HYDROXYPROLINE AND GROWTH*JCI Insight, 1962
- SOME EFFECTS OF HUMAN GROWTH HORMONE ON RENAL HEMODYNAMICS AND ON TUBULAR PHOSPHATE TRANSPORT IN MAN*JCI Insight, 1962
- A specific method for the analysis of hydroxyproline in tissues and urineAnalytical Biochemistry, 1960
- IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MANJCI Insight, 1960