Inhibitory Effect of Bicarbonate on ATP Levels and Cholesterol Biosynthesis in Liver Homogenates.
- 1 November 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 105 (2), 383-387
- https://doi.org/10.3181/00379727-105-26118
Abstract
Bicarbonate is a potent inhibitor of a system essential for maintenance of ATP levels that are required for conversion of mevalonic acid to non-saponifiable material (largely cholesterol) by liver homogenates. This bicarbonate inhibition, over a narrow range of concentration, is reversed by trypsin-ized protamine or by amino acids of the urea cycle or by canavanine.Keywords
This publication has 5 references indexed in Scilit:
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- Relationship Between Mevalonic Acid Utilization and ATP Content in Liver Homogenates Pretreated with Ribonuclease.Experimental Biology and Medicine, 1959
- Ribonuclease Inhibition of Mevalonic Acid Utilization.Experimental Biology and Medicine, 1958
- Factors Influencing Incorporation of Mevalonic Acid into Cholesterol by Rat Liver Homogenates.Experimental Biology and Medicine, 1957
- THE ROLE OF DEOXYRIBONUCLEIC ACID AND OTHER POLYNUCLEOTIDES IN ATP SYNTHESIS BY ISOLATED CELL NUCLEIProceedings of the National Academy of Sciences, 1957