Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1
- 16 September 1994
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 265 (5179), 1728-1732
- https://doi.org/10.1126/science.7916164
Abstract
After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point mutations in which allow expression to spread into adjacent rhombomeres. Retinoids and their nuclear receptors may therefore participate in sharpening segment-restricted expression of Hoxb-1 during rhombomere boundary formation.Keywords
This publication has 39 references indexed in Scilit:
- A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1Nature, 1994
- Mechanisms of transactivation by retinoic acid receptorsBioEssays, 1993
- Reversal of axonal pathways from rhombomere 3 correlates with extra hox expression domainsNeuron, 1993
- The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentationCell, 1993
- Retinoic acid and craniofacial development: Molecules and morphogenesisBioEssays, 1993
- Multiplicity generates diversity in the retinoic acid signalling pathwaysTrends in Biochemical Sciences, 1992
- Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signallingNature, 1992
- Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrainNature, 1989
- Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouseNature, 1989
- Segmental patterns of neuronal development in the chick hindbrainNature, 1989