Genetic control of resistance to murine malaria
- 1 January 1984
- journal article
- research article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 24 (1), 91-102
- https://doi.org/10.1002/jcb.240240108
Abstract
Strain variation in the level of resistance to malaria was investigated in inbred mice after infection with Plasmodium chabaudi. Following intraperitoneal infection with the typing dose of parasitized erythrocytes, mice of 11 inbred strains could be separated using survival time as the criterium into resistant and susceptible groups. Genetic analysis of F1 hybrid and backcross progeny derived from one of the most resistant (B10.A) and from the most susceptible (A/J) strains as parents suggested that host resistance in this strain combination was genetically controlled by a dominant, non‐H‐2‐linked, autosomal gene or closely linked genes. Analysis of the mechanisms of resistance to P chabaudi showed (1) phenotypic expression of the resistance gene was apparent within 6 days of infection as a significant difference between resistant and susceptible mice in the level of parasitemia; (2) the level of host NK cell activity was not related to the level of host resistance to malaria; (3) compared with susceptible A/J mice, resistant B1O.A hosts had an augmented erythropoietic response during the course of malaria as well as during phenylhydrazine‐induced anemia and (4) treatment with BCG or P acnes resulted in an equal degree of protection, measured by parasitemia and survival, in both resistant and susceptible mice.Keywords
This publication has 28 references indexed in Scilit:
- Apparent irrelevance of NK cells to resolution of infections with Babesia microti and Plasmodium vinckei petteri in miceParasite Immunology, 1982
- Killing of the malarial parasite Plasmodium yoelii in vitro by cells of myeloid originParasite Immunology, 1982
- Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouseNature, 1981
- Early enhancement followed by suppression of natural killer cell activity during murine malarial infectionsImmunology Letters, 1981
- Differences in susceptibility of various mouse strains to haemoprotozoan infections: possible correlation with natural killer activityParasite Immunology, 1980
- Macrophage activation for tumor cytotoxicity: Genetic variation in macrophage tumoricidal capacity among mouse strainsCellular Immunology, 1979
- A fluorescent immunoassay for the quantification of C-reactive proteinJournal of Immunological Methods, 1978
- The course of a Plasmodium berghei infection in six different mouse strainsZeitschrift Fur Parasitenkunde-Parasitology Research, 1977
- Protection of mice against Babesia, and Plasmodium with BCGNature, 1976
- The Influence of Strain, Sex and Age of Mice on Infection with Plasmodium BergheiThe Journal of Infectious Diseases, 1953