Effect of Dibenzyline Treatment on Cardiac Dynamics and Oxidative Metabolism in Hemorrhagic Shock

Abstract

Thirty splenectomized, heparinized, mongrel dogs were placed in hemorrhagic shock by removal of 30% of the blood volume over 30 minutes. They were maintained in shock for 60 minutes and 16 dogs were then treated with dibenzyline and 14 dogs with saline and the animals observed for an additional hour. Compared to saline-treated controls dibenzyline-treated animals demonstrated a significant fall in blood pressure accompanied by a fall in peripheral resistance and a stable cardiac output, at the same time the animals exhibited decreased oxygen consumption, increased oxygen debt and increased metabolic acidosis, indicating increased ischemia at a cellular level. It was concluded that dibenzyline given under the conditions of this experiment promoted deterioration of some of the metabolic responses to shock.