Lack of dose‐response effect of terfenadine on resting bronchomotor tone in patients with asthma
- 1 May 1991
- journal article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 21 (3), 363-366
- https://doi.org/10.1111/j.1365-2222.1991.tb01669.x
Abstract
Bronchodilatation data from three, four-period cross-over studies were combined to assess the effect of oral terfenadine 60, 120, 180 mg and placebo on the airways of 26 patients with atopic asthma. Meta-analysis of these data showed that mean changes in FEV1 from pre-dose to 4 hr were 11.4, 14.6 and 11.8% for the three doses of terfenadine, respectively, and -2.9% for placebo. There was a significant treatment effect (P = 0.0001) but no effect of dose. Terfenadine, a non-sedating histamine H1-receptor antagonist, caused bronchodilatation in a single dose. Whether this effect is sustained with long-term treatment requires further investigation.Keywords
This publication has 12 references indexed in Scilit:
- The Contribution of Histamine to Immediate Bronchoconstriction Provoked by Inhaled Allergen and Adenosine 5′ Monophosphate in Atopic AsthmaAmerican Review of Respiratory Disease, 1987
- Effect of terfenadine on methacholine-induced bronchoconstriction in asthmaJournal of Allergy and Clinical Immunology, 1987
- Terfenadine in exercise induced asthma.BMJ, 1984
- Bronchodilator effects of the H1 receptor antagonist--clemastine.Archives of Disease in Childhood, 1983
- A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthmaClinical and Experimental Allergy, 1982
- Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine.British Journal of Clinical Pharmacology, 1982
- Histamine Receptors in Normal Human BronchiClinical Science, 1980
- Effect of an inhaled antihistamine (clemastine) as a bronchodilator and as a maintenance treatment in asthma.Thorax, 1979
- Bronchodilatation after inhalation of the antihistamine clemastine.Thorax, 1978
- Further studies on the mechanism of human histamine-induced asthma *1The effect of an aerosolized H1 receptor antagonist (diphenhydramine)Journal of Allergy and Clinical Immunology, 1977