A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthma
- 1 July 1982
- journal article
- research article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 12 (4), 355-361
- https://doi.org/10.1111/j.1365-2222.1982.tb02539.x
Abstract
Exercise-induced asthma (EIA) was provoked by a standardized treadmill running for 8 min in 7 atopic adult asthmatics. The tests were performed using a double-dummy technique after placebo, oral ketotifen, inhaled clemastine, ipratropium bromide and sodium cromoglycate (SCG), in a random single blind-fashion on different days. The mean post-exercise percentage fall in forced expiratory volume in 1 s (FEV1) was 47 (SE 6.95), 39 (SE 8.35), 27 (SE 7.17), 23 (SE 7.69) and 7.0 (SE 4.62)%, respectively. There was significantly less mean bronchoconstriction with SCG (P < 0.01), ipratropium bromide and clemastine (P < 0.05) but not with ketotifen. Six of 7 individual patients had significant protection of EIA with sodium cromoglycate, 4 with ipratropium bromide, 3 with clemastine but only 1 with ketotifen. Ipratropium bromide and clemastine were bronchodilators at rest, wheras SCG and ketotifen were not. Despite its claims to work as a mast cell stabilizing drug, ketotifen in a single dose does not have an effect similar to sodium cromoglycate in EIA, nor does it compare with inhaled clemastine or ipratropium bromide.This publication has 14 references indexed in Scilit:
- Actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction.BMJ, 1981
- Effect of an inhaled antihistamine on exercise-induced asthma.Thorax, 1980
- Cholinergic blockade in the prevention of exercise-induced asthma.Thorax, 1980
- Ketotifen in adult asthma.BMJ, 1980
- Exercise-Induced AsthmaNew England Journal of Medicine, 1979
- Inhaled antihistamines--bronchodilatation and effects on histamine- and methacholine-induced bronchoconstriction.Thorax, 1978
- Sodium cromoglycate and ipratropium bromide in exercise-induced asthma.Thorax, 1978
- Histamine release in exercise-induced asthma.BMJ, 1978
- Inhibition of exercise-induced asthma by different pharmacological pathways.Thorax, 1976
- Effect of Disodium Cromoglycate on Exercise-induced AsthmaBMJ, 1968