BIOLOGICAL AND BIOCHEMICAL PROPERTIES OF THE ANALOGUE ANTIBIOTIC TUBERCIDIN
- 1 August 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 52 (2), 493-501
- https://doi.org/10.1073/pnas.52.2.493
Abstract
The adenosine analogue, Tubercidin, is lethally incorporated into both the cellular functions and nucleic acids of mouse leukemic fibroblasts and the viruses contained therein. Presently, it is the only analogue known to be incorporated into RNA and DNA. Since Tubercidin (Tu) and its derivatives, desamino-Tu and deoxy-Tu, are not converted into corresponding guanine analogues, the specificity of the involved enzymes could be dependent upon the imidazole portion of the purine.Keywords
This publication has 19 references indexed in Scilit:
- CYTOTOXICITY AND ANTITUMOR PROPERTIES OF THE ABNORMAL NUCLEOSIDE TUBERCIDIN (NSC-56408).1964
- THE SECONDARY STRUCTURE OF REOVIRUS RNAProceedings of the National Academy of Sciences, 1963
- ACTION OF ACTINOMYCIN DON ANIMAL CELLS AND VIRUSEProceedings of the National Academy of Sciences, 1962
- DEOXYRIBONUCLEIC ACID-DIRECTED SYNTHESIS OF RIBONUCLEIC ACID BY AN ENZYME FROM ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1962
- EFFECT OF MITOMYCIN C ON THE GROWTH OF SOME ANIMAL VIRUSESProceedings of the National Academy of Sciences, 1961
- Nucleic acid synthesis and the division cycle in x-irradiated l-strain mouse cellsBiochimica et Biophysica Acta, 1961
- Amino Acid Metabolism in Mammalian Cell CulturesScience, 1959
- Formation of two- and three-Stranded Helical Molecules by Polyinosinic Acid and Polyadenylic AcidNature, 1958
- A NEW ANTIBIOTIC, TUBERCIDIN1957
- A new method for the isolation of ribonucleic acids from mammalian tissuesBiochemical Journal, 1956