THE INFLUENCE OF PIPERIDINOMETHYLBENZODIOXANE (933F) ON THE ACTION OF SYMPATHIN

Abstract

1. The positive ino-tropic effect on a recipient frog''s heart perfused with sympathin from another frog''s heart or from the aq. humor of a cat is abolished by 933F. The response of the donor heart to stimulation of its own sympathetic nerve supply is unaffected by 933F. The destruction of sympathin in vitro is accelerated by 933F. These observations render unlikely the view that the difference between the effect of 933F on sympathetic nerve stimulation and on adrenalin is due to a difference between sympathin and adrenalin.