Synthetic methods for polyamine linkers and their application to combinatorial chemistry
- 1 March 1997
- journal article
- Published by Springer Nature in Molecular Diversity
- Vol. 2 (3), 165-170
- https://doi.org/10.1007/bf01682204
Abstract
Polyamines and polyamine conjugates display a diverse range of important biological functions, ranging from antibiotics to immunosuppressants and glutamate receptor antagonists. For these reasons, polyamines provide an excellent template/scaffold for combinatorial chemistry. In this paper we present methods for the solid-phase immobilisation of polyamines for use in synthetic and combinatorial chemistry and describe how they have been employed in the preparation of a number of important polyamine conjugates and polyamine libraries. Thus, we have designed, synthesised and utilised a number of polyamine linkers for both solution and resin screening combinatorial application.Keywords
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