Metabolism of Mannose by the Extrahepatic Tissues

Abstract

Mannose, like glucose and galactose, will pass from the extracellular to the intracellular compartment of the extra-hepatic tissues. Insulin accelerates the rate of this transfer. Glucose reduces the rate at which mannose is transferred into the cells under insulin action. In the eviscerated non-nephrectomized rabbit mannose injected into the blood is very largely excreted by the kidney, proving that little if any circulating mannose is changed to glucose by this preparation. The extrahepatic tissues under insulin action oxidize con-siderable amounts of mannose to CO2.