Plasma Lipid Interrelationships in Experimental Nephrosis1

Abstract

Sequential changes and interrelation-ships among the plasma lipid fractions were studied in rats injected with antikidney serum, and in nephrotic rats infused with fat or with phosphatide. The results are consistent with the concept that the AKS-induced deficiency of plasma albumin primarily induces an intravascu-lar retention of plasma triglycerides. The accumulation of cholesterol and phospholipid in nephrotic plasma appears to be a passive derangement secondary to the lipid-sequestering properties of the increment of excess triglycerides in such plasma.