Effect of flavanone on mixed-function oxidase and conjugation reactions in rats
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (1), 11-16
- https://doi.org/10.3109/00498258709047170
Abstract
1. Flavanone administered to female Fischer 344 rats (1.00mmol/kg per day for seven days) did not induce ethylmorphine demethylation, aniline hydroxylation, hexobarbital oxidation or aldrin epoxidation. 2. Flavanone at 0.05mmol/kg per day for seven days increased glutathione-S- transferase activity with 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(p-nitrophenoxy) propane as substrates. 3. Flavanone at 0.05 mmol/kg per day for seven days increased the glucuronidation of 1-naphthol, and at 0.20 mmol/kg increased the glucuronidation of chloramphenicol. 4. Flavanone administration did not alter sulphotransferase activity with 2-naphthol as the substrate and did not enhance glutathione-S-transferase or glucuronyltransferase activity when added in vitro.This publication has 11 references indexed in Scilit:
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