Chromosomal reallocation of the chickenc-myblocus and organization of 3′-proximal coding exons

Abstract

In the course of our studies concerning the tissue-specific expression of the c-myb proto-oncogene, we have established the nucleotide sequence of the chicken c-myb 3′-proximal coding exons. In situ hybridization performed with different genomic DNA probes corresponding to nearly all the c-myb gene allowed us to localize the corresponding locus on the large acrocentric chromosome 3 in chicken. Our sequencing data also indicate that the 3′-proximal noncoding sequences represented in c-myb mRNA species are derived from non-contiguous exons