Three-Point Association of HLA-A,B,Bf Haplotypes Deduced in 200 Parents of 100 Families
- 1 May 1977
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 6 (5), 459-464
- https://doi.org/10.1111/j.1365-3083.1977.tb02103.x
Abstract
The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters, and chi-square values were determined both from the genotype and from the phenotype data. Although the HLA-B,Bf associations involve antigens that are also present in the highly associated A,B and B,D haplotypes of the Caucasian population, there was--with the possible exception of HLA-A3,B7,Bf-S--no significant three-point association for HLA-A,B,Bf.Keywords
This publication has 3 references indexed in Scilit:
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- EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENTThe Journal of Experimental Medicine, 1974