ACTIVATION OF GUANYLATE CYCLASE BY STREPTOZOTOCIN AND 1-METHYL-1-NITROSOUREA
- 1 January 1977
- journal article
- research article
- Vol. 37 (1), 28-31
Abstract
Streptozotocin was shown to induce a variety of tumors in rats. Streptozotocin and 1-methyl-1-nitrosourea, a component of the streptozotocin molecule and a known carcinogen, stimulate guanylate cyclase which catalyzes the production of cyclic GMP. At a maximal concentration of 3 mg/ml, these agents activated guanylate cyclase .apprx. 30-fold in liver, 20-fold in kidney, 15-fold in cerebellum, 15- to 30-fold in cerebrum, 4- to 20-fold in heart, 12-fold in brain stem, 10-fold in lung and 2-fold in pancreas. Since recent evidence suggests a role for cyclic GMP in malignant transformation, the data may help explain the tumor-inducing capacity of these agents.This publication has 4 references indexed in Scilit:
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