A novel macromolecular antibiotic, SN-07. Taxonomy of producing organism, isolation, characterization and biological activities.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (12), 1670-1676
- https://doi.org/10.7164/antibiotics.38.1670
Abstract
A novel macromolecular antibiotic SN-07 was obtained from the cultural supernatant of Actinomadura roseoviolacea var. miuraeusis nov. var. The antibiotic was soluble in water, had a molecular weight of 18, 000-22, 000 daltons in 50mM Tris-HCl buffer, pH 7.0, containing 2.0 M KCl as compared with authentic proteins. Its major constituents were nucleic acids. The substance had antibacterial activity against Gram-positive bacteria. It was also effective against lymphocytic leukemia P388 in vivo.This publication has 5 references indexed in Scilit:
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