G gamma delta beta thalassaemia and g gamma HPFH (Hb Kenya type): comparison of 2 new cases.
Open Access
- 1 August 1977
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 14 (4), 237-244
- https://doi.org/10.1136/jmg.14.4.237
Abstract
Two new cases of G gamma delta beta thalassaemia and G gamma HPFH (Hb Kenya type) have been characterised in detail and compared with regard to haematological data, globin chains biosynthesis, and intracellular distribution of Hb F. The similarities and differences between these two conditions are discussed in relation to the possible underlying defects at the molecular level and to the control of the gamma delta beta gene complex in general.Keywords
This publication has 41 references indexed in Scilit:
- δβ-Thalassemia is due to a gene deletionCell, 1976
- The Kenya Form of Hereditary Persistence of Fetal Haemoglobin: Structural Studies and Evidence for Homogeneous Distribution of Haemoglobin F using Fluorescent Anti-haemoglobin F AntibodiesBritish Journal of Haematology, 1976
- Hereditary persistence of foetal haemoglobin with β-chain synthesis in cis position (Gγ-β+-HPFH) in a negro familyNature, 1976
- Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal HaemoglobinActa Haematologica, 1975
- β-Thalassemia in the American NegroJournal of Clinical Investigation, 1973
- A Homozygote for the HbGγType of Foetal Haemoglobin in India: A Study of Two Indian and Four Negro FamiliesBritish Journal of Haematology, 1972
- The synthesis of human haemoglobin A2 during erythroid maturationBiochemical and Biophysical Research Communications, 1972
- Nature of Foetal Haemoglobin in F-ThalassaemiaBritish Journal of Haematology, 1971
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Biochemical Phenotypes of Thalassemia in the American Negro Population*Annals of the New York Academy of Sciences, 1964