Experimental Studies of Acute Renal Failure. I. The Protctive Effect of Mannitol
- 1 January 1963
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 89 (1), 1-6
- https://doi.org/10.1016/s0022-5347(17)64488-4
Abstract
The effects of mannitol upon renal injury was determined. Male Sprague-Dawley rats, after preparation on a low Na, acid-ash diet and dehydration for 24 hours, were injected with methemoglobin prepared from out-dated human blood (2 gm/kg). Mannitol was given in a dose of 0.3 gm/kg immediately after. Death from renal failure occurred in 1.1% of the mannitol treated and 93.5% of the control animals.Keywords
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