A STUDY OF THE RENAL CIRCULATION, TUBULAR FUNCTION AND MORPHOLOGY, AND URINARY VOLUME AND COMPOSITION IN DOGS FOLLOWING MERCURY POISONING AND TRANSFUSION OF HUMAN BLOOD 1

Abstract

Mercury bichloride given intramusc. had regularly produced renal damage in dogs studied 48-120 hours later. Anuria or severe oliguria was found only when renal ischemia was present. Human blood transfusions had occasionally caused renal damage in dogs studied 48-72 hours after transfusion. Again anuria or severe oliguria were recorded only when renal ischemia was present. No evidence of intra-renal "shunting" of blood could be demonstrated by renal arteriography in either category. The pathogenesis of anuria in these conditions is discussed in light of the present results.