Lymphoblastoid Cell Lines are Polyclonal Activators of Human T Lymphocytes
- 1 February 1979
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 9 (2), 151-158
- https://doi.org/10.1111/j.1365-3083.1979.tb02717.x
Abstract
Following stimulation with autologous or allogeneic lymphoblastoid cell lines (LCL) human T lymphocytes acquire two properties which suggest that LCL act as polyclonal activators. Cytotoxic activity, which has an antigen-specific component, is produced towards normal lymphocytes and LCL, and the cells become capable of mounting proliferative responses to antigens on human B lymphocytes which have accelerated secondary-type kinetics. Only weak responses to autologous cells occur. In addition, repeated restimulation with the original LCL leads to a progressive increase in the number of cells in the culture for a period of about 4 weeks. This approach may prove a useful way to grow large numbers of human T lymphocytes for further study.This publication has 17 references indexed in Scilit:
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