Prediction of peak penicillin and cephalosporin concentrations in canine serum as derived from in vitro serum and tissue quantitative protein binding

Abstract

Peak serum concentrations of four penicillin and two cephalosporin antibiotics were predicted from quantitative antibiotic binding to serum and tissue proteins in dogs. Predicted total peak serum antibiotic levels varied from 5.1 mg/l00 ml for the 17.0% canine serum-bound methicillin to 16.5 mg/100 ml for the 83.6% serum-bound nafcillin. Actual peak antibiotic concentrations measured following rapid intravenous injection into dogs were in agreement with predicted concentrations for all drugs except nafcillin.