Effect of Prolonged Ingestion of γ-Linolenate by MS Patients
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 17 (2), 67-76
- https://doi.org/10.1159/000114926
Abstract
The absolute electrophoretic mobility of erythrocytes from MS patients is reduced in the presence of 0.08 mg/ml of linoleic or arachidonic acid, whilst that of normal or other neurological disease patients is increased in the presence of these acids. When an MS patient ingests γ-linolenate (in capsule form equivalent to 413.4 mg of γ-linolenic acid and 2.664 g of linoleic acid per day) the reaction of MS erythrocytes begins to change. After 3 or 4 months the reaction becomes normal with arachidonic acid (i.e. mobility is speeded up) and 2 months or so later this occurs also with linoleic acid. Very prolonged administration of γ-linolenate leads to a markedly increased sensitivity to the effect of prostaglandins (PGE2) on RBC mobility. The observations are interpreted to mean the induction of a biochemical-biophysical change in the membranes, and the significance of this in the aetiology and treatment of multiple sclerosis is discussed.Keywords
This publication has 5 references indexed in Scilit:
- The activity of γ-linolenate and dihomo-γ-linolenate methyl esters in vitro and in vivo on blood platelet function in non-human primates and in manThrombosis Research, 1977
- Erythrocyte-UFA (Eufa) mobility test for multiple sclerosis: Implications for pathogenesis and handling of the diseaseZeitschrift für Neurologie, 1977
- MIXED LYMPHOCYTE REACTION IN MULTIPLE SCLEROSISActa Neurologica Scandinavica, 1976
- RED BLOOD CELL SIZE IN MULTIPLE SCLEROSISActa Neurologica Scandinavica, 1968
- ALLERGIC ENCEPHALOMYELITIS INDUCED BY BRAIN ANTIGEN AFTER DEFICIENCY IN POLYUNSATURATED FATTY ACIDS DURING MYELINATIONActa Neurologica Scandinavica, 1967