THE ANTIKETOGENIC ACTIVITY OF SUCCINIC ACID

Abstract

Fed in quantities of 10 to 50 gs. per day succinic acid had no antiketogenic activity in the human diabetic when measured by the ketonuria. In a normal fasting person it was as antiketogenic as an equivalent amt. of glucose to which succinic acid is converted in the phloridzinized and probably in the normal organism. The ketosis of fasting rats was reduced in the same degree by glucose as by an equivalent amt. of succinic acid. These compounds were equally good hepatic glycogen formers in the rat.