ANTILUTEOMATOUS ACTION OF PROGESTERONE IN THE GUINEA-PIG

Abstract

In expts. on 33 guinea pigs, autoplastic grafts of one ovary were made into the spleen, the other ovary being removed. The luteomatous condition of the ovarian stroma arising 10 mos. after such grafting was counteracted by progesterone, when allowed to act for at least 3 mos. before necropsy. No luteal cords were present in the stroma of these grafts. They contained large clusters of small non-luteinized cells of follicular origin. The antiluteomatous action of progesterone was selective, in so far as the development of Graffian and hemorrhagic follicles in the intrasplenic graft was unimpaired by progesterone. When progesterone was lacking in the body, the luteal cords of the stroma reappeared in the graft.