PROGESTERONE AND DESOXYCORTICOSTERONE IN THE STEROID CONTROL OF THE GONADOTROPHIC FUNCTION OF THE HYPOPHYSIS (Exemplified by the Behavior of the Intrasplenic Ovarian Graft in the Guinea Pig)

Publisher Website
Google Scholar
Abstract
- Blood follicles and cystic follicles which are a most characteristic feature of the intrasplenic ovarian graft in the castrated guinea pig fail to appear when [alpha]a -estradiol is administered. On the contrary, [alpha]a-estradiol greatly enhances production of corpora lutea which, when no estrogen is administered, are scarce in similar grafts in the castrated guinea pig at 2 mos. after transplantation. When progesterone is administered follicular development with production of blood follicles and cystic follicles is not inhibited; luteinization is slightly inhibited. When [alpha]a-estradiol and progesterone are administered simultaneously there are no blood follicles and there is no luteinization, that is progesterone counteracts the stimulative action of estrogen on luteinization but not the estrogenic control of follicular growth. The problem of the interplay of the 2 essential ovarian steroids in the control of the hypo-physeal gonadotrophic function is discussed. Desoxycorticosterone acts similarlyto progesterone.