EFFECTS OF ADRENALECTOMY AND DESOXYCORTICOSTERONE SUBSTITUTION THERAPY ON THE CASTRATED RAT PROSTATE EVIDENCE FOR AN ANDROMIMETIC FUNCTION OF THE IMMATURE RAT ADRENAL
- 1 November 1941
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 29 (5), 746-754
- https://doi.org/10.1210/endo-29-5-746
Abstract
Prostate wts. were reduced by 50%, with marked histological degeneration, following adrenalectomy in immature castrated rats. The prostate degeneration was not prevented when adrenalec-tomized castrated rats were maintained with a body growth rate 93% of that of castrated controls by means of desoxycorticosterone acetate. The rat adrenal evidently is capable of secreting physiologically appreciable amts. of androgens during a certain phase in the development of the sexually immature animal.This publication has 8 references indexed in Scilit:
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