THE EFFECT OF COELIAC GANGLIONECTOMY ON THE SUGAR TOLERANCE OF DOGS

Abstract

In all, 10 dogs were studied before and after celiac ganglionectomy. The intravenous sugar tolerance of normal dogs did not vary spontaneously under basal conditions in over 50 determinations. The removal of the celiac ganglion resulted in a decided, persistent rise in tolerance in every instance. Intravenously ad ministered dextrose disappeared more rapidly from the blood stream than before the operation. The dogs be came more susceptible to insulin. Denervation of the liver in 2 dogs did not have a similar action. These data show that the celiac ganglion mediates nerve im pulses, the exclusion of which brings about either an increased insulin production or a reduction in the insulin requirement.