Enantioselective Borohydride Reduction of Ketones Catalyzed by Optically Active Cobalt(II) Complexes: Achievement of High Enantioselection by Modified Borohydrides with Furfuryl Alcohol Derivatives
- 1 September 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 25 (9), 737-738
- https://doi.org/10.1246/cl.1996.737
Abstract
The enantioselective borohydride reduction of ketones catalyzed by optically active (β-oxoaldiminato) cobalt(II) complexes was remarkably improved by using the borohydride which was modified with furfuryl alcohol dervatives and ethanol. In the presence of 1 mol% of the above complex catalysts, asymmetric reduction of aromatic ketones proceeded smoothly to give the corresponding optically active alcohols in quantitative yields within 6–12 h with high enantiomeric excesses (90–97% ee).Keywords
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