ANALYSIS OF ANOMALOUS pKB VALUES FOR METIAMIDE AND ATROPINE IN THE ISOLATED STOMACH OF THE MOUSE
- 1 September 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 67 (1), 59-65
- https://doi.org/10.1111/j.1476-5381.1979.tb16106.x
Abstract
1 In the isolated, lumen-perfused, stomach preparation of the mouse, metiamide was found by kinetic analysis to behave like a simple competitive antagonist of histamine-stimulated acid secretion. However, the pKB estimate of 5.08 was significantly lower than that found in guinea-pig atrium (6.0) or rat uterus (6.1) suggesting that H2-receptors might not be homogeneous.Keywords
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