Serum homocysteine in routine evaluation of potential vitamin B12 and folate deficiency
- 1 September 1990
- journal article
- research article
- Published by Wiley in European Journal of Haematology
- Vol. 45 (3), 143-149
- https://doi.org/10.1111/j.1600-0609.1990.tb00441.x
Abstract
Total serum homocysteine (Hcy) was measured in patients with either low serum folate, low serum vitamin B12 (B12), or potential metabolic defects, in order to evaluate Hcy as an indicator of the tissue status of the two vitamins. An increased Hcy supported the diagnosis of frank tissue deficiency in those patients in whom tissue deficiency was evident by other means. A Hcy within the reference interval enabled the clinician to identify those patients whose low serum vitamin level and symptoms did not reflect a tissue deficiency of B12 or folate of clinical consequence. Children with inherited disturbances of B12 metabolism, and whose serum B12 was within the reference interval, were correctly identified by an increased Hcy. A declining Hcy was evidence of correction of a deficiency even when other laboratory or clinical measurements of a response were obscured.Keywords
This publication has 19 references indexed in Scilit:
- Plasma cobalamin-binding and serum cobalamin in patients with folate deficiencyScandinavian Journal of Haematology, 2009
- Cobalamin Deficiency and Neuropsychiatric DisordersNew England Journal of Medicine, 1988
- Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or MacrocytosisNew England Journal of Medicine, 1988
- Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.JCI Insight, 1988
- Incidence and clinical significance of protein‐bound vitamin B12 malabsorptionEuropean Journal of Haematology, 1987
- FALSE LOW SERUM VITAMIN B12 VALUES WITH RADIODILUTION ASSAYS USING BLOCKED R-BINDERSThe Lancet, 1983
- Changes in Serum Levels of Cobalamin and Cobalamin Analogues in Folate DeficiencyScandinavian Journal of Haematology, 1981
- PROBLEMS WITH THE SERUM VITAMIN B12 ASSAYThe Lancet, 1980
- Effect of Alcohol on Serum Folate LevelJCI Insight, 1973
- Aseptic addition method for Lactobacillus casei assay of folate activity in human serumJournal of Clinical Pathology, 1966