Rapid Pulmonary Removal of 5-Hydroxytryptamine in the Intact Dog.
- 1 March 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 118 (3), 797-800
- https://doi.org/10.3181/00379727-118-29974
Abstract
Summary Simultaneous injection of indocyanine green dye and C14 5-HT was done in dogs to determine the extent of pulmonary removal of 5-HT. Cardiac output determined from C14 data was consistently higher than by the dye method, indicating immediate removal of 5-HT in the pulmonary bed. The mean removal was 33%, and was not changed by prior administration of β-phenylisopropylhydrazine, a monoamine oxidase inhibitor.Keywords
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