Variations in Vascular Reactivity Produced by Season, Cold Stress and Immaturity; Role of Thyroid and Adrenal Cortex
- 31 December 1952
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 172 (1), 118-128
- https://doi.org/10.1152/ajplegacy.1952.172.1.118
Abstract
Seasonal variations in the reactions of over 500 isolated adult swine carotid arteries studied by a plethysmographic technic over a 30-month period in a single laboratory are described. In winter (Nov. through Apr.) vasoconstriction to epinephrine and acethylcholine is shorter and the reaction to histamine is longer than in summer. The arteries of swine of <12 kg. and of thyroidectomized swine have a pattern of vascular reactivity similar to winter-killed adult swine. In the vessels from the thyroidectomized swine this pattern reverted to normal when DL-thyroxine was added to the perfusate. Acute cold stress did not duplicate the seasonal changes. The histamine response in arteries of adrenalectomized pigs was prolonged; cortisone (2:106) shortened this reaction to normal. No changes occurred in the reaction of these arteries to epinephrine or acetylcholine. Inhibition of amino oxidase, cholinesterase and histaminase resulted in an increase . in the % vasoconstriction and duration of the reaction of normal isolated arteries to L-epinephrine, acetylcholine and histamine, respectively. Evidence is presented suggesting that the seasonal and age variations in vascular reactivity may be partially due to variations in the tissue level of thyroid hormone.Keywords
This publication has 6 references indexed in Scilit:
- Constriction of Isolated Arteries and Their Vasa Vasorum Produced by Low TemperaturesAmerican Journal of Physiology-Legacy Content, 1952
- In Vitro Studies of the Coronary Arteries of Man and Swine as Demonstrated by a New Technic, AngioplethysmokymographyCirculation, 1951
- The inhibition of histaminase by amidinesBiochemical Journal, 1951
- In vitro Action of Cortisone on Vasoconstriction Due to Histamine.Experimental Biology and Medicine, 1951
- EASE OF RELEASE OF HISTAMINE FROM THE LUNGS OF GUINEA‐PIGSImmunology & Cell Biology, 1949
- Iodine Deficiency in Newborn Sheep and SwineJournal of Animal Science, 1948