Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
Open Access
- 21 May 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 264 (2), 187-192
- https://doi.org/10.1016/0014-5793(90)80245-e
Abstract
The cyclic heptapeptide, microcystin‐LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with K i, values below 0.1 nM. Protein phosphatase 2B is inhibited 1000‐fold less potently, while six othe...Keywords
This publication has 29 references indexed in Scilit:
- Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxinExperimental Cell Research, 1989
- An improved procedure for identifying and quantitating protein phosphatases in mammalian tissuesFEBS Letters, 1989
- THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASESAnnual Review of Biochemistry, 1989
- Effects on human health of some toxic cyanobacteria (blue‐green algae) in reservoirs, lakes, and riversEnvironmental Toxicology and Water Quality, 1989
- Apparent “activation” of protein kinases by okadaic acid class tumor promotersBiochemical and Biophysical Research Communications, 1989
- Cellular effects of cyanobacterial peptide toxinsEnvironmental Toxicology and Water Quality, 1988
- Effects of the peptide toxin from Microcystis aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cellsChemico-Biological Interactions, 1987
- Distribution of Microcystis aeruginosa Peptide Toxin and Interactions with Hepatic Microsomes in MiceBasic & Clinical Pharmacology & Toxicology, 1987
- The Protein Phosphatases Involved in Cellular Regulation. 5. Purification and Properties of a Ca2+ /Calmodulin-Dependent Protein Phosphatase (2B) from Rabbit Skeletal MuscleEuropean Journal of Biochemistry, 1983
- Separation and Characterisation of Glycogen Synthase Kinase 3,Glycogen Synthase Kinase 4 and Glycogen Synthase Kinase 5 from Rabbit Skeletal MuscleEuropean Journal of Biochemistry, 1982