Evidence That High Telomerase Activity May Induce a Senescent-like Growth Arrest in Human Fibroblasts
Open Access
- 1 February 2003
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 278 (9), 7692-7698
- https://doi.org/10.1074/jbc.m212944200
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Clonal Variation in Phenotype and Life Span of Human Embryonic Fibroblasts (MRC-5) Transduced with the Catalytic Component of Telomerase (hTERT)Experimental Cell Research, 2001
- Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditionsGenes & Development, 2001
- Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cellsProceedings of the National Academy of Sciences, 2001
- Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of ProliferationExperimental Cell Research, 2000
- Human Endothelial Cell Life Extension by Telomerase ExpressionJournal of Biological Chemistry, 1999
- Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cellsNature, 1998
- Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life spanCurrent Biology, 1998
- Extension of Life-Span by Introduction of Telomerase into Normal Human CellsScience, 1998
- Bypass of Senescence After Disruption of p21
CIP1/WAF1
Gene in Normal Diploid Human FibroblastsScience, 1997
- The serial cultivation of human diploid cell strainsExperimental Cell Research, 1961