Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides

Abstract

The esters of adenosine-5''-carboxylic acid represent a new class of potent nontoxic coronary vasodilators. The ethyl ester which is active by an intraduodenal or i.v. route in dogs, causes a large increase in coronary sinus PO2 [O2 partial pressure] and coronary blood flow. Due to the pronounced vasoactive properties of adenosine-5''-carboxylic acid esters a systematic study of the corresponding amides was performed. Several other analogs containing the N1-oxide function of 2'',3'' substituents were studied.