Interaction Between Crystalline Penicillin and Human Plasma Proteins
- 19 January 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 101 (2612), 67-68
- https://doi.org/10.1126/science.101.2612.67
Abstract
Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.This publication has 10 references indexed in Scilit:
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