Antagonism by DDT of the Effect of Valinomycin on a Synthetic Membrane
- 15 May 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3933), 841-843
- https://doi.org/10.1126/science.168.3933.841
Abstract
The potassium conductance which is induced by 10-6 molar valinomycin in a lecithin-decane membrane is reversed by 3 x 10-6 molar DDT. Membranes not treated with valinomycin are not affected by DDT. This blockade of potassium conductance parallels the effect of DDT on axonic conduction. Dieldrin and lindane, whose physiological actions are in some ways like those of DDT, do not affect valinomycin-induced conductance of lecithin-decane membranes.Keywords
This publication has 18 references indexed in Scilit:
- Mechanism of alkali cation transport in bulk membranes using macrotetrolide antibioticsBiochemical and Biophysical Research Communications, 1969
- New Halocyclopropane Insecticides and the Mode of Action of DDTNature, 1969
- Chlorinated hydrocarbon insecticides: Inhibition of rabbit brain ATPase activitiesJournal of Neurochemistry, 1969
- Action Potentials induced in Biomolecular Lipid MembranesNature, 1968
- Pharmacological Modifications of the Sodium Channels of Frog NerveThe Journal of general physiology, 1968
- Dieldrin: Interaction with Nerve Components of CockroachesScience, 1966
- Lipid Films as Transducers for Detection of Antigen-Antibody and Enzyme-Substrate ReactionsScience, 1966
- DDT: A New Hypothesis of Its Mode of ActionScience, 1964
- Structure-Toxicity in Hexachlorocyclohexane IsomersScience, 1955
- THE EFFECT OF INSECTICIDES ON THE ACTION POTENTIALS OF INSECT NERVECanadian Journal of Zoology, 1954