In search of an enzyme: the β-secretase of Alzheimer's disease is an aspartic proteinase
- 1 November 2000
- journal article
- review article
- Published by Elsevier in Trends in Neurosciences
- Vol. 23 (11), 565-570
- https://doi.org/10.1016/s0166-2236(00)01647-7
Abstract
No abstract availableThis publication has 60 references indexed in Scilit:
- Identification of a Novel Aspartic Protease (Asp 2) as β-SecretaseMolecular and Cellular Neuroscience, 1999
- BACE Maps to Chromosome 11 and a BACE Homolog, BACE2 , Reside in the Obligate Down Syndrome Region of Chromosome 21Science, 1999
- Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N CellsThe Journal of cell biology, 1997
- Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In VivoNeuron, 1996
- Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin DJournal of Biological Chemistry, 1996
- Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin DBioorganic & Medicinal Chemistry Letters, 1996
- Amyloid β-peptide is produced by cultured cells during normal metabolismNature, 1992
- Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursorBiochemical and Biophysical Research Communications, 1992
- Alzheimer's disease amyloid β-clipping enzyme (APP secretase): Identification, purification, and characterization of the enzymeBiochemical and Biophysical Research Communications, 1991
- Putative N‐terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cellsFEBS Letters, 1989