Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro.
Open Access
- 1 April 1984
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 21 (2), 129-132
- https://doi.org/10.1136/jmg.21.2.129
Abstract
The male contraceptive agent gossypol was found to induce a dose related increase of DNA strand breaks in human fibroblasts in vitro at concentrations of 5 to 40 micrograms/ml. The effect was reduced in the presence of 2% fetal calf serum. A weak but reproducible increase in the SCE frequency was found in human lymphocytes treated for 1 hour in serum-free medium with 0.04 to 4 micrograms/ml of gossypol.This publication has 20 references indexed in Scilit:
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