In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
- 1 February 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (4), 1227-1231
- https://doi.org/10.1073/pnas.85.4.1227
Abstract
To determine which cells within the brain produce .beta.-amyloid mRNA and to assess expression of the .beta.-amyloid gene in Alzheimer disease, we analyzed brain tissue from Alzheimer and control patients by in situ hybridization. Our results demonstrate that .beta.-amyloid mRNA is produced by neurons in the nucleus basilis of Meynert and cerebral cortex and that nucleus basalis perikarya from Alzheimer patients consistently hybridize more .beta.-amyloid probe than those from controls. These observations support the hypothesis that increased expression of the .beta.-amyloid gene plays an important role in the deposition of amyloid in the brains of patient with Alzheimer disease.This publication has 26 references indexed in Scilit:
- The Amyloid β Protein Gene Is Not Duplicated in Brains from Patients with Alzheimer's DiseaseScience, 1987
- Gene Dosage of the Amyloid β Precursor Protein in Alzheimer's DiseaseScience, 1987
- Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's DiseaseScience, 1987
- Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer LocusScience, 1987
- Altered structural proteins in plaques and tangles: What do they tell us about the biology of Alzheimer's disease?Neurobiology of Aging, 1986
- THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGESNeuropathology and Applied Neurobiology, 1986
- Alzheimer's DiseaseNew England Journal of Medicine, 1986
- Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril proteinBiochemical and Biophysical Research Communications, 1984
- Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probesDevelopmental Biology, 1984
- Some morphometric aspects of the brain in senile dementia of the alzheimer typeAnnals of Neurology, 1981