Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe

Abstract

Multimodal imaging has been driven by the realization that no single imaging method has a complete solution to the multifaceted challenges of disease diagnosis and prognosis. For example, the addition of molecular imaging to the current functional and structural imaging methods requires procedures that report molecular events without loss of anatomical information. A common practice today is to combine methods with high spatial resolution such as magnetic resonance imaging (MRI), x-ray computed tomography (CT), and ultrasound with those with high detection sensitivity such as positron emission tomography (PET) and diffuse optical tomography (DOT).