Serological Detection of Deoxyribonucleic Acid (DNA) Adsorbed to Formalinized Erythrocytes.
- 1 June 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 98 (2), 300-303
- https://doi.org/10.3181/00379727-98-24024
Abstract
A new technique is described for the serological detection of desoxyribonucleic acid (DNA). Specific agglutination of formalinized erythrocytes coupled with DNA from normal or tumor tissue by anti-DNAP serum offered the tool with which this detection is possible. Agglutination and specific inhibition studies with DNA coupled erythrocytes revealed that DNA probably functions as a hapten, i.e. the DNA confers serological specificity, but it must be coupled with a protein to elicit antibody formation or to be detected by precipitation or coupled to cells for agglutination reactions.Keywords
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