PRODUCTION OF EXOPHTHALMOS IN FUNDULUS HETEROCLITUS (VAR. BERMUDAE) BY TRIIODOTHYRONINE AND DESICCATED THYROID12
- 1 March 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 60 (3), 390-392
- https://doi.org/10.1210/endo-60-3-390
Abstract
THE usual clinical and experimental presumption has been that exophthalmos is due to an excess of a pituitary substance. Exophthalmos has been produced repeatedly in the thyroidectomized guinea pig by pituitary preparations (1 and 2). Desiccated thyroid (2) and thyroxine (1) are reported not to produce exophthalmos in this animal. Exophthalmos has also been produced b}’ pituitary extract in Fundulus heteroclitus (3). The present studies were designed with the above background to test the clinical assumption that additional thyroid would antagonize the exophthalmos which occurred during treatment of thyrotoxicosis. However, the results were at variance with the above work.Keywords
This publication has 4 references indexed in Scilit:
- THE THYROID STIMULATING HORMONE OF THE ANTERIOR PITUITARY AS DISTINCT FROM THE EXOPHTHALMOS PRODUCING SUBSTANCE1Endocrinology, 1953
- THE EXPERIMENTAL PRODUCTION OF EXOPHTHALMOS IN FUNDULUS BY MEANS OF ANTERIOR PITUITARY EXTRACTS1Endocrinology, 1945
- The histology of orbital and other fat tissue deposits in animals with experimentally produced exophthalmos1939
- THE EXOPHTHALMOS OF GRAVESʼ DISEASE. ITS EXPERIMENTAL PRODUCTION AND SIGNIFICANCEThe American Journal of the Medical Sciences, 1934