Critical test evaluation of micronized mebendazole againstAnoplocephala Perfoljatain the horse

Abstract

Extract Mebendazole (methyl 5(6)benzoyl 1–2 benzimidazole carbamate) has recently been shown to have high anthelmintic efficacy against a wide range of benzimidazole-susceptible equine nematodes (Callear and Neave, 1971 Callear, T. F. F. and Neave, R. M. S. 1971. The clinical use of the anthelmintic mebendazole. Br. vet. J., 127: 9–11. [Google Scholar] ; Walker and Knight, 1972 Walker, D. and Knight, D. 1972. The anthelmintic activity of mebendazole: A field trial in horses. Vet. Rec., 90: 58–65. [Google Scholar] ; Bennett, 1973 Bennett, D. G. 1973. Efficacy of mebendazole as an anthelmintic in horses. Vet. Med./Small Anim. Clin., 68: 604–609. [Google Scholar] ; Bradley and Radhakrishnan, 1973 Callear, T. F. F. and Neave, R. M. S. 1971. The clinical use of the anthelmintic mebendazole. Br. vet. J., 127: 9–11. [Google Scholar] ; Neave and Callear, 1973 Neave, R. M. S. and Callear, T. F. F. 1973. Further clinical studies on the use of mebendazole (R 17635) as an anthelmintic in horses. Br. vet. J., 129: 79–82. [Google Scholar] ; Reinecke and LeRoux, 1973 Reinecke, R. K. and LeRoux, D J. 1973. Anthelmintic activity of mebendazole in equines. J. South African vet. med. Ass., 43: 287–294. [Google Scholar] ). However, its activity against equine cestodes is generally reported to be unsatisfactory — e.g., Bradley and Radhakrishnan (1973) Callear, T. F. F. and Neave, R. M. S. 1971. The clinical use of the anthelmintic mebendazole. Br. vet. J., 127: 9–11. [Google Scholar] , using mebendazole at a dose rate of 9 mg/kg (administered either per os or by stomach tube), did not observe significant anthelmintic efficacy against Anoplocephala spp. in horses. Similar results were reported by Drudge et al. (1974) Drudge, T. H. , Lyons, E. T. and Tolliver, S. C. 1974. Critical and clinical test evaluations of mebendazole against internal parasites of the horse. Am. J. vet. Res., 35: 1409–1413. [Google Scholar] for mebendazole (8.8 mg/kg administered by stomach tube) against both Anoplocephala magna and A. perfoliata.