Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance
Open Access
- 1 January 2013
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 4, 315
- https://doi.org/10.3389/fimmu.2013.00315
Abstract
The importance of regulatory T cells in balancing the effector arm of the immune system is well documented, playing a central role in preventing autoimmunity, facilitating graft tolerance following organ transplantation, and having a detrimental impact on the development of anti-tumor immunity. These regulatory responses use a variety of mechanisms to mediate suppression, including soluble factors. While IL-10 and TGF-β are the most commonly studied immunosuppressive cytokines, the recently identified IL-35 has been shown to have potent suppressive function in vitro and in vivo. Furthermore, not only does IL-35 have the ability to directly suppress effector T cell responses, it is also able to expand regulatory responses by propagating infectious tolerance and generating a potent population of IL-35-expressing inducible regulatory T cells. In this review, we summarize research characterizing the structure and function of IL-35, examine its role in disease, and discuss how it can contribute to the induction of a distinct population of inducible regulatory T cells.Keywords
This publication has 66 references indexed in Scilit:
- Faculty Opinions recommendation of Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.Published by H1 Connect ,2017
- IL-12 family cytokines: immunological playmakersNature Immunology, 2012
- Identification and manipulation of tumor associated macrophages in human cancersJournal of Translational Medicine, 2011
- The inhibitory cytokine IL-35 contributes to regulatory T-cell functionNature, 2007
- Interleukin-12: Biological Properties and Clinical ApplicationClinical Cancer Research, 2007
- Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cellsImmunological Reviews, 2001
- Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.The Journal of Experimental Medicine, 1978
- Infectious immunological tolerance.1971
- Cell interactions in the induction of tolerance: the role of thymic lymphocytes.1970
- Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in MiceScience, 1969