FURTHER STUDIES ON THE METABOLISM OF THERAPEUTIC DOSES OF NATURAL ESTROGENS IN HUMAN SUBJECTS*
- 1 January 1948
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 8 (1), 67-75
- https://doi.org/10.1210/jcem-8-1-67
Abstract
Studies of the fractionation and photometric estimation of urinary estrogens were made following the admn. of therapeutic doses of the natural estrogens to (a) a normal human [male], (b) a bilaterally orchiectomized human [male] and (c) a human [male] with extensive liver damage. The nature and amt. of the estrogens excreted is influenced by (a) the vehicle in which the hormone is administered (b) the route of admn., and (c) the nature of chemical conjugation of the administered hormone. In the presence of extensive liver damage, the reversible conversion of estradiol to estrone is not impaired but conversion of either to estriol is negligible and the estrogens are excreted in the free form.Keywords
This publication has 4 references indexed in Scilit:
- THE METABOLISM OF SINGLE THERAPEUTIC DOSES OF THE NATURAL ESTROGENS IN HUMAN SUBJECTS*Journal of Clinical Endocrinology & Metabolism, 1947
- THE UTILIZATION OF A COLOR CORRECTION EQUATION WITH THE KOBER REAGENT FOR THE ESTIMATION OF THE ESTROGENS IN HUMAN URINE WITH LOW ESTROGEN CONTENTJournal of Biological Chemistry, 1946
- THE FRACTIONATION AND PHOTOMETRIC ESTIMATION OF THE ESTROGENS IN HUMAN PREGNANCY URINEJournal of Biological Chemistry, 1946
- Excretion of Estrogen After the Injection of Estradiol and Estrone into Men with Cirrhosis of the LiverJournal of Clinical Endocrinology & Metabolism, 1944