Biosynthesis and distribution of opioid peptides
- 11 April 1983
- journal article
- review article
- Published by Springer Nature in Journal of Endocrinological Investigation
- Vol. 6 (2), 139-149
- https://doi.org/10.1007/bf03350587
Abstract
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides. However, potent biologic activity of Group III opioid peptides and existence of opiate-receptors specific for these peptides (k receptors) strongly suggest that Group III opioid peptides are not precursors of Leu-enkephalin but bioactive substances per se. Further studies should clarify details of the processing of proenkephalin B.Keywords
This publication has 28 references indexed in Scilit:
- Methionine-enkephalin and leucine-enkephalin in human sympathoadrenal system and pheochromocytoma.Journal of Clinical Investigation, 1982
- A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.Proceedings of the National Academy of Sciences, 1981
- Concomitant Secretion of Adrenocorticotropin, β-Endorphin, and γ-Melanotropin from Perfused Pituitary Tumor Cells of Cushing's Disease: Effects of Lysine Vasopressin, Rat Median Eminence Extracts, Thyrotropin-Releasing Hormone, and Luteinizing Hormone-Releasing Hormone∗Journal of Clinical Endocrinology & Metabolism, 1981
- CONCOMITANT SECRETION OF γ-MSH WITH ACTH AND β-ENDORPHIN IN HUMANSJournal of Clinical Endocrinology & Metabolism, 1980
- Existence of γ-melanotropin (γ-MSH)-like immunoreactivity in bovine and human pituitary glandsBiochemical and Biophysical Research Communications, 1980
- Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.Proceedings of the National Academy of Sciences, 1979
- Dynorphin-(1-13), an extraordinarily potent opioid peptide.Proceedings of the National Academy of Sciences, 1979
- Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursorNature, 1979
- A large product of cell-free translation of messenger RNA coding for corticotropin.Proceedings of the National Academy of Sciences, 1976
- Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.Proceedings of the National Academy of Sciences, 1976